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A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

Abstract:

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP). Specifically, we identify 6-phosphogluoconate dehydrogenase (6PGD) as an androgen-regulated gene that is upregulated in prostate cancer. AR increased the expression of 6PGD indirectly via activation of sterol regulatory element binding protein 1 (SREBP1)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.62592

Authors


Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
10
Article number:
e62592
Publication date:
2021-08-12
Acceptance date:
2021-08-11
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pmid:
34382934
Language:
English
Keywords:
Pubs id:
1190883
Local pid:
pubs:1190883
Deposit date:
2021-08-14

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