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Deterioration of metabolic coronary regulation in hemorrhagic shock. Role of hypoxia and the renin-angiotensin system.

Abstract:

The effect of hypoxia and the renin-angiotensin system on metabolic coronary regulation in hemorrhagic shock was studied in 22 anesthetized open-chest dogs. Left circumflex coronary blood flow was measured with an electromagnetic flowmeter. Dogs were ventilated with room air (n = 8) or 100% oxygen (n = 7). A third group of dogs was ventilated with room air and bilaterally nephrectomized 5 h prior to starting the experimental protocol (n = 7). After control data had been obtained, dogs were bl...

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Publisher copy:
10.1007/bf01851849

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Publisher:
Springer-Verlag
Journal:
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
Volume:
185
Issue:
6
Pages:
429-443
Publication date:
1985-01-01
DOI:
EISSN:
1433-8580
ISSN:
0300-9130
URN:
uuid:cbf627b0-ae3d-4d21-b6bb-5ed076e2a5a7
Source identifiers:
441446
Local pid:
pubs:441446

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