- Abstract:
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Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 920.1kb)
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- Publisher copy:
- 10.1016/j.jconrel.2015.05.265
-
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- Publisher:
- Elsevier B.V. Publisher's website
- Journal:
- Journal of controlled release: official journal of the Controlled Release Society Journal website
- Volume:
- 210
- Pages:
- 10-18
- Publication date:
- 2015-05-12
- Acceptance date:
- 2015-05-10
- DOI:
- EISSN:
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1873-4995
- ISSN:
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0168-3659
- URN:
-
uuid:cbf613b9-e01d-4a14-844d-616e7fda9660
- Source identifiers:
-
523320
- Local pid:
- pubs:523320
- Copyright holder:
- Steven Mo et al.
- Copyright date:
- 2015
- Notes:
-
This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/ published by Elsevier in Journal of Controlled Release on 2015-05-12, available online: http://dx.doi.org/10.1016/j.ultramic.2015.03.005).
Journal article
Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours
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