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Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Abstract:

Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.jconrel.2015.05.265

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
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Publisher:
Elsevier B.V. Publisher's website
Journal:
Journal of controlled release: official journal of the Controlled Release Society Journal website
Volume:
210
Pages:
10-18
Publication date:
2015-05-12
Acceptance date:
2015-05-10
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:cbf613b9-e01d-4a14-844d-616e7fda9660
Source identifiers:
523320
Local pid:
pubs:523320

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