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A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

Abstract:

The SH2 domain-containing leukocyte protein of 76 kD (SLP-76) is a pivotal element of the signaling machinery controlling T cell receptor (TCR)-mediated activation. Here, we identify 14-3-3epsilon and zeta proteins as SLP-76 binding partners. This interaction was induced by TCR ligation and required phosphorylation of SLP-76 at serine 376. Ribonucleic acid interference and in vitro phosphorylation experiments showed that serine 376 is the target of the hematopoietic progenitor kinase 1 (HPK-1...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20062066

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Journal:
The Journal of experimental medicine
Volume:
204
Issue:
3
Pages:
681-691
Publication date:
2007-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:cbee2001-770e-416a-9a43-7ffd7a3541ec
Source identifiers:
27747
Local pid:
pubs:27747

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