Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex.

Journal article

BACKGROUND: Decreased expression of proteins such as synaptophysin in the hippocampus and prefrontal cortex in schizophrenia is suggestive of synaptic pathology. However, the overall profile of changes is unclear. AIMS: To investigate synaptophysin gene expression in the cerebral cortex in schizophrenia. METHOD: The dorsolateral prefrontal (Brodmann area [BA] 9/46), anterior cingulate (BA 24), superior temporal (BA 22) and occipital (BA 17) cortex were studied in two series of brains, totalli...

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Authors: Eastwood, S; Cairns, N; Harrison, P

• Publication status: Published
• Journal: British journal of psychiatry : the journal of mental science
• Volume: 176
• Issue: 3
• Pages: 236-242
• Publication date: 2000-03-01
• DOI: 10.1192/bjp.176.3.236
• EISSN: 1472-1465
• ISSN: 0007-1250
• Language: English
• Keywords: Female; Regression Analysis; Synaptophysin; Humans; Gene Expression; Schizophrenia; Autoradiography; Aged; Cerebral Cortex; Blotting, Western; Case-Control Studies; RNA, Messenger; In Situ Hybridization; Aged, 80 and over; Middle Aged; Adult; Male