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Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.

Abstract:
6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.
Publication status:
Published

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Journal:
Lancet
Volume:
1
Issue:
8478
Pages:
411-414
Publication date:
1986-02-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
196451

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