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Journal article

Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars

Abstract:

Objective

Weight gain predisposes to increased intrahepatic triglycerides (IHTG) and insulin resistance (IR), but these do not occur in all obese subjects. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG, while ceramides, which synthesis is induced by saturated fatty acids and endotoxin, are key mediators of IR. We hypothesized that dietary macronutrient composition influences the mechanisms and magnitude of weight gain-in...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2337/dc18-0071

Authors


Luukkonen, PK More by this author
Sädevirta, S More by this author
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Care Journal website
Volume:
41
Issue:
8
Pages:
1732-1739
Publication date:
2018-05-29
Acceptance date:
2018-05-01
DOI:
EISSN:
1935-5548
ISSN:
0149-5992
Pubs id:
pubs:854529
URN:
uri:cbe850c9-fc6e-4ba8-8c71-b5c03a22c74d
UUID:
uuid:cbe850c9-fc6e-4ba8-8c71-b5c03a22c74d
Local pid:
pubs:854529

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