Journal article
Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block
- Abstract:
-
Background and Purpose Two new technologies are likely to revolutionize cardiac safety and drug development: in vitro experiments on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and in silico human adult ventricular cardiomyocyte (hAdultV-CM) models. Their combination was recently proposed as a potential replacement for the present hERG-based QT study for pharmacological safety assessments. Here, we systematically compared in silico the effects of...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 3.3MB)
-
- Publisher copy:
- 10.1111/bph.13282
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Rodriguez, B
Grant:
Senior ResearchFellowship in Basic Biomedical Science
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- British Journal of Pharmacology Journal website
- Volume:
- 172
- Issue:
- 21
- Pages:
- 5147-5160
- Publication date:
- 2015-10-15
- Acceptance date:
- 2015-08-03
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- Source identifiers:
-
539378
Item Description
- Language:
- English
- Pubs id:
-
pubs:539378
- UUID:
-
uuid:cbd6441e-c62d-43d5-99cf-a2684e8a174a
- Local pid:
- pubs:539378
- Deposit date:
- 2015-11-12
Terms of use
- Copyright holder:
- Paci et al
- Copyright date:
- 2015
- Rights statement:
- Copyright © 2015 The Authors. British Journal of Pharmacology published by John Wiley and Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record