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Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.

Abstract:

Two new technologies are likely to revolutionize cardiac safety and drug development: in vitro experiments on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and in silico human adult ventricular cardiomyocyte (hAdultV-CM) models. Their combination was recently proposed as a potential replacement for the present hERG-based QT study for pharmacological safety assessments. Here, we systematically compared in silico the effects of selective ionic current block on hiPSC-CM ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/bph.13282

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
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Funding agency for:
Rodriguez, B
Publisher:
Wiley Publisher's website
Journal:
British journal of pharmacology Journal website
Volume:
172
Issue:
21
Pages:
5147-5160
Publication date:
2015-11-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:cbd6441e-c62d-43d5-99cf-a2684e8a174a
Source identifiers:
539378
Local pid:
pubs:539378
Language:
English

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