- Abstract:
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Two new technologies are likely to revolutionize cardiac safety and drug development: in vitro experiments on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and in silico human adult ventricular cardiomyocyte (hAdultV-CM) models. Their combination was recently proposed as a potential replacement for the present hERG-based QT study for pharmacological safety assessments. Here, we systematically compared in silico the effects of selective ionic current block on hiPSC-CM ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.3MB)
-
- Publisher copy:
- 10.1111/bph.13282
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- British journal of pharmacology Journal website
- Volume:
- 172
- Issue:
- 21
- Pages:
- 5147-5160
- Publication date:
- 2015-11-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
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0007-1188
- URN:
-
uuid:cbd6441e-c62d-43d5-99cf-a2684e8a174a
- Source identifiers:
-
539378
- Local pid:
- pubs:539378
- Language:
- English
- Copyright holder:
- Paci et al.
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 The Authors. British Journal of Pharmacology published by John Wiley and Sons Ltd on behalf of British Pharmacological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.
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