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Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

Abstract:

BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with multiple susceptibility genes. We have previously reported suggestive linkage to the chromosomal region 14q21-q23 in Finnish SLE families. PRINCIPAL FINDINGS: Genetic fine mapping of this region in the same family material, together with a large collection of parent affected trios from UK and two independent case-control cohorts from Finland and Sweden, indicated that a novel uncharacterized gene, MAMDC1 (MA...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0008037

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Swedish Research Council More from this funder
Finland Research Council More from this funder
Helsinki University Central Hospital Research Fund More from this funder
Welander-Finsen Foundation More from this funder
Helsinki Biomedical Graduate School LERU PhD Program in Biomedicine More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
12
Article number:
e8037
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
7820

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