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Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology.

Abstract:

Mammalian cells are rapidly becoming the system of choice for the production of recombinant glycoproteins for structural biology applications. Their use has enabled the structural investigation of a whole new set of targets including large, multi-domain and highly glycosylated eukaryotic cell surface receptors and their supra-molecular assemblies. We summarize the technical advances that have been made in mammalian expression technology and highlight some of the structural insights that have ...

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Publication status:
Published

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Publisher copy:
10.1016/j.sbi.2013.04.003

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Current opinion in structural biology More from this journal
Volume:
23
Issue:
3
Pages:
345-356
Publication date:
2013-06-01
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Language:
English
Keywords:
Pubs id:
pubs:401807
UUID:
uuid:cbc90394-c13e-4f25-b006-9713e0dadb91
Local pid:
pubs:401807
Source identifiers:
401807
Deposit date:
2013-11-17

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