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A full genome search in multiple sclerosis.

Abstract:

The aetiology of multiple sclerosis (MS) is uncertain. There is strong circumstantial evidence to indicate it is an autoimmune complex trait. Risks for first degree relatives are increased some 20 fold over the general population. Twin studies have shown monozygotic concordance rates of 25-30% compared to 4% for dizygotic twins and siblings. Studies of adoptees and half sibs show that familial risk is determined by genes, but environmental factors strongly influence observed geographic differ...

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Publication status:
Published

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Publisher copy:
10.1038/ng0896-472

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Nature genetics More from this journal
Volume:
13
Issue:
4
Pages:
472-476
Publication date:
1996-08-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Keywords:
Pubs id:
pubs:35945
UUID:
uuid:cbbfe339-a36d-4805-8d8f-05ad1eac5d4d
Local pid:
pubs:35945
Source identifiers:
35945
Deposit date:
2012-12-19

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