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Do intracerebral cytokine responses explain the harmful effects of dexamethasone in HIV-associated cryptococcal meningitis?

Abstract:
Background The CryptoDex trial showed dexamethasone was associated with poorer clinical outcomes and slower fungal clearance in HIV-associated cryptococcal meningitis. We analysed CSF cytokine concentrations from CrytpoDex participants over the first week of treatment to investigate potential mechanisms of harm and test two hypotheses: dexamethasone reduced pro-inflammatory cytokine concentrations leading to poorer outcomes; and leukotriene A4 hydrolase (LTA4H) genotype (prev... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/cid/ciy725

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
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Funding agency for:
Day, JN
Department for International Development More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
68
Issue:
9
Pages:
1494–1501
Publication date:
2018-08-30
Acceptance date:
2018-08-16
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:911247
URN:
uri:cbbbdf56-9f45-4d45-8db9-50c057cd0e5a
UUID:
uuid:cbbbdf56-9f45-4d45-8db9-50c057cd0e5a
Local pid:
pubs:911247

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