A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children.

Journal article

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Authors: Jenkins, N; Mwangi, T; Kortok, M; Marsh, K; Craig, A

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 41
• Issue: 12
• Pages: 1817-1819
• Publication date: 2005-12-01
• DOI: 10.1086/498156
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Humans; Incidence; Fever; Malaria; Polymorphism, Genetic; Infection; Intercellular Adhesion Molecule-1; Infant; Kenya