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A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children.

Abstract:
An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.
Publication status:
Published

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Publisher copy:
10.1086/498156

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America More from this journal
Volume:
41
Issue:
12
Pages:
1817-1819
Publication date:
2005-12-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Language:
English
Keywords:
Pubs id:
pubs:39765
UUID:
uuid:cbb88ffd-fe0d-4666-9473-330907617175
Local pid:
pubs:39765
Source identifiers:
39765
Deposit date:
2012-12-19

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