Journal article icon

Journal article

Concentration-dependent mortality of chloroquine in overdose

Abstract:

Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose. In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as yet there is no convincing evidence of clinical efficacy. Bayesian regression models were fitted to survival outcomes and electrocardiograph QRS durations from 302 prospectively...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-5524-0325
More by this author
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-4566-4030
More by this author
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
9
Article number:
e58631
Place of publication:
England
Publication date:
2020-07-08
Acceptance date:
2020-07-07
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pmid:
32639233
Language:
English
Keywords:
Pubs id:
1119102
Local pid:
pubs:1119102
Deposit date:
2020-08-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP