Journal article
Concentration-dependent mortality of chloroquine in overdose
- Abstract:
-
Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose. In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as yet there is no convincing evidence of clinical efficacy. Bayesian regression models were fitted to survival outcomes and electrocardiograph QRS durations from 302 prospectively...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 9
- Article number:
- e58631
- Place of publication:
- England
- Publication date:
- 2020-07-08
- Acceptance date:
- 2020-07-07
- DOI:
- EISSN:
-
2050-084X
- ISSN:
-
2050-084X
- Pmid:
-
32639233
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1119102
- Local pid:
- pubs:1119102
- Deposit date:
- 2020-08-21
Terms of use
- Copyright holder:
- Watson et al.
- Copyright date:
- 2020
- Rights statement:
- © Copyright Watson et al. Thisarticle is distributed under theterms of theCreative CommonsAttribution License,whichpermits unrestricted use andredistribution provided that theoriginal author and source arecredited.
- Licence:
- CC Attribution (CC BY)
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