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Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma.

Abstract:

We have previously reported that human T cell receptors (TcR) selected in the class II-restricted (HLA-DRB1*1302) response to a tetanus toxin peptide (tt830-843) frequently used the V beta 2 germ-line segment which paired with several V alpha segments and that the putative CDR3 of both alpha and beta chains showed remarkable heterogeneity. To analyze the structural basis for recognition of the tt830-843/DR complex, five of these TcR were reconstituted into a murine T cell hybridoma, 58 alpha-...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830231203

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
23
Issue:
12
Pages:
3057-3065
Publication date:
1993-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:cbb2ba9e-a0a5-4742-a8d7-40f25ad7fff6
Source identifiers:
11239
Local pid:
pubs:11239

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