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DNA-coated gold nanoparticles for the detection of mRNA in live Hydra Vulgaris animals

Abstract:

Advances in nanoparticle design have led to the development of nanoparticulate systems that can sense intracellular molecules, alter cellular processes, and release drugs to specific targets in vitro. In this work, we demonstrate that oligonucleotide-coated gold nanoparticles are suitable for the detection of mRNA in live Hydra vulgaris, a model organism, without affecting the animal's integrity. We specifically focus on the detection of Hymyc1 mRNA, which is responsible for the regulation of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/acsami.8b17846

Authors


Kyriazi, M-E More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
ORCID:
0000-0001-8706-1292
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
ORCID:
0000-0002-6538-3036
Tortiglione, C More by this author
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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Applied Materials and Interfaces Journal website
Publication date:
2018-12-11
Acceptance date:
2018-11-26
DOI:
EISSN:
1944-8252
ISSN:
1944-8244
Pubs id:
pubs:952814
URN:
uri:cbaabb59-96cd-4f2c-b95d-171e92c5a83b
UUID:
uuid:cbaabb59-96cd-4f2c-b95d-171e92c5a83b
Local pid:
pubs:952814

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