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Journal article

Cutaneous squamous cell carcinoma (SCC) and the DNA damage response: pATM expression patterns in pre-malignant and malignant keratinocyte skin lesions.

Abstract:

Recent evidence suggests that an initial barrier to the emergence of tumours is a DNA damage response that evokes a counter-response which arrests the growth of, or eliminates, damaged cells. Early precursor lesions express markers of an activated DNA damage response in several types of tumour, with a diminishing response in more advanced cancers. An important marker of DNA damage is ATM which becomes phosphorylated (pATM) upon activation. We have investigated pATM expression patterns in cult...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0021271

Authors


Harwood, C More by this author
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Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
7
Pages:
Article: e21271
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:cba810d2-9c9d-436c-92f7-a25e71b9cc25
Source identifiers:
175441
Local pid:
pubs:175441

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