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Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents.

Abstract:

Covariation in the structural composition of the gut microbiome and the spectroscopically derived metabolic phenotype (metabotype) of a rodent model for obesity were investigated using a range of multivariate statistical tools. Urine and plasma samples from three strains of 10-week-old male Zucker rats (obese (fa/fa, n=8), lean (fa/-, n=8) and lean (-/-, n=8)) were characterized via high-resolution 1H NMR spectroscopy, and in parallel, the fecal microbial composition was investigated using fl...

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Publication status:
Published

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Publisher copy:
10.1021/pr8009885

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Journal:
Journal of proteome research More from this journal
Volume:
8
Issue:
5
Pages:
2361-2375
Publication date:
2009-05-01
DOI:
EISSN:
1535-3907
ISSN:
1535-3893

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