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Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects.

Abstract:

AIM: To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance. METHODS: In a sequentially assigned crossover treatment study, pregnant women with uncomplicated falciparum malaria received i.v. artesunate (i.v. ARS) (4mgkg(-1) ) on the first day and oral ARS (4mgkg(-1) ) on the second, or, oral on the first and i.v. on the second, in both groups follo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Rijken, MJ More by this author
Tarning, J More by this author
Lindegardh, N More by this author
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Journal:
British journal of clinical pharmacology
Volume:
73
Issue:
3
Pages:
467-477
Publication date:
2012-03-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:cba0b67f-7abc-403f-9e46-85fbb4fd002f
Source identifiers:
180572
Local pid:
pubs:180572

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