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Journal article

Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.

Abstract:

BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly understood. A large body of evidence indicates that silencing is more efficient on the X chromosome than on autosomes, leading to the idea that the X chromosome has acquired sequences that facilita...

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Publication status:
Published

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Publisher copy:
10.1186/1756-8935-3-10

Authors


Huntley, D More by this author
Montana, G More by this author
Nesterova, TB More by this author
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Journal:
Epigenetics and chromatin
Volume:
3
Issue:
1
Pages:
10
Publication date:
2010
DOI:
EISSN:
1756-8935
ISSN:
1756-8935
URN:
uuid:cb9d7d1a-421f-42d6-adda-cae6139df32c
Source identifiers:
99749
Local pid:
pubs:99749
Language:
English

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