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Journal article

Passive sexual transmission of human immunodeficiency virus type 1 variants and adaptation in new hosts.

Abstract:

Human immunodeficiency virus type 1 (HIV-1) genetic diversity is a major obstacle for the design of a successful vaccine. Certain viral polymorphisms encode human leukocyte antigen (HLA)-associated immune escape, potentially overcoming limited vaccine protection. Although transmission of immune escape variants has been reported, the overall extent to which this phenomenon occurs in populations and the degree to which it contributes to HIV-1 viral evolution are unknown. Selection on the HIV-1 ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02014-05

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Edwards, CT More by this author
McCarthy, N More by this author
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Journal:
Journal of virology
Volume:
80
Issue:
14
Pages:
7226-7234
Publication date:
2006-07-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:cb985a0b-0389-48bb-8088-d75a2aa13b78
Source identifiers:
28051
Local pid:
pubs:28051

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