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A microtubule interactome: complexes with roles in cell cycle and mitosis.

Abstract:

The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and altering their properties. We have used a MT cosedimentation assay, combined with 1D and 2D PAGE and mass spectrometry, to identify over 250 MAPs from early Drosophila embryos. W...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.0060098

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
Fisher, K
Grant:
Oxford Life Sciences Interface/Doctoral Training Centre Studentship
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Funding agency for:
Garcia, A
Grant:
Ramon y Cajal Research Fellow
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Funding agency for:
Wakefield, J
Grant:
Lectureship at Oxford Life Sciences Interface/Doctoral Training Centre
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
6
Issue:
4
Pages:
e98
Publication date:
2008-04-22
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Source identifiers:
56321
Language:
English
Keywords:
Pubs id:
pubs:56321
UUID:
uuid:cb96ba1d-5fed-47c7-b0cf-11e2143fae36
Local pid:
pubs:56321
Deposit date:
2012-12-19

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