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Journal article

Optical sensor-based oxygen tension measurements correspond with hypoxia marker binding in three human tumor xenograft lines.

Abstract:

Hypoxia has a negative effect on the outcome of radiotherapy and surgery and is also related to an increased incidence of distant metastasis. In this study, tumor pO(2) measurements using a newly developed time-resolved luminescence-based optical sensor (OxyLitetrade mark) were compared with bioreductive hypoxia marker binding (pimonidazole). Single pO(2) measurements per tumor were compared to hypoxia marker binding in tissue sections using image analysis. Both assays were performed in the s...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Radiation research More from this journal
Volume:
154
Issue:
5
Pages:
547-555
Publication date:
2000-11-01
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
Language:
English
Keywords:
Pubs id:
pubs:131185
UUID:
uuid:cb93f5c3-6b35-4551-89ca-43d3bb3a5d87
Local pid:
pubs:131185
Source identifiers:
131185
Deposit date:
2013-11-17

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