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Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha.

Abstract:

Collagen-induced arthritis is the most widely used animal model for the evaluation of novel therapeutic strategies for rheumatoid arthritis. The disease is induced by immunization of genetically susceptible strains of mice or rats with type II collagen in adjuvant. Susceptibility to collagen-induced arthritis is associated with major histocompatibility complex (MHC) class II genes, although non-MHC genes also play a role. Both B- and T-lymphocytes are important in the pathogenesis of collagen...

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Publisher copy:
10.1385/1-59745-208-4:265

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
361
Pages:
265-284
Publication date:
2007
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:cb91f62f-da18-44ba-8626-6bea7feb2920
Source identifiers:
226810
Local pid:
pubs:226810

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