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Impaired proliferation and migration in human Miller-Dieker neural precursors.

Abstract:

OBJECTIVE: Miller-Dieker syndrome (MDS) is a malformation of cortical development that results in lissencephaly (meaning smooth brain). This disorder is caused by heterozygous deletions on chromosome 17p13.3, including the lissencephaly 1 (LIS1) gene. Various mouse models have been used as an experimental paradigm in understanding human lissencephaly, but clear limitations exist in these studies, particularly because mice are naturally lissencephalic. Thus, the objective of this article was ...

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Publication status:
Published

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Publisher copy:
10.1002/ana.20843

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Journal:
Annals of neurology More from this journal
Volume:
60
Issue:
1
Pages:
137-144
Publication date:
2006-07-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Language:
English
Keywords:
Pubs id:
pubs:71037
UUID:
uuid:cb8f42bd-bd9f-4952-a0ef-7d48e2d932ce
Local pid:
pubs:71037
Source identifiers:
71037
Deposit date:
2012-12-19

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