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Journal article

Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification.

Abstract:

VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because HSCs derive from arterial cells, it is unclear whether VEGFA directly contributes to HSC specification. This is an important question for our understanding of how HSCs are formed and for developing their production in vitro. Through knockdown of the regulato...

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Publication status:
Published

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Journal:
Developmental cell
Volume:
24
Issue:
2
Pages:
144-158
Publication date:
2013-01-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:cb87322e-88a3-4b75-9bae-8de3a9c93d34
Source identifiers:
374227
Local pid:
pubs:374227

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