- Abstract:
-
CD6 is a type I T cell surface receptor which modulates antigen receptor signalling. Its activity is regulated by binding of its membrane proximal domain (domain 3) to a cell surface ligand, CD166. CD6 monoclonal antibodies (mAbs) specific for the membrane distal domain (domain 1) perturb CD6 function including itolizumab (Alzumab™) which has reached the clinic for treatment of autoimmune disease. We characterised molecular and functional properties of several CD6 mAbs including itolizumab to...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.5mb)
-
- Publisher copy:
- 10.1111/imm.12952
-
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- Publisher:
- John Wiley & Sons Ltd Publisher's website
- Journal:
- Immunology Journal website
- Volume:
- 155
- Issue:
- 2
- Pages:
- 273-282
- Publication date:
- 2018-06-13
- Acceptance date:
- 2018-05-11
- DOI:
- EISSN:
-
1365-2567
- ISSN:
-
0019-2805
- Pubs id:
-
pubs:852265
- URN:
-
uri:cb871e93-af75-44af-8331-ebad49db76e0
- UUID:
-
uuid:cb871e93-af75-44af-8331-ebad49db76e0
- Local pid:
- pubs:852265
- Copyright holder:
- John Wiley & Sons Ltd
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 John Wiley & Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/imm.12952
Journal article
CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action
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