Journal article icon

Journal article

Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells.

Abstract:

Dendritic cells (DC) are key regulators of immune responses. Mature DC are traditionally considered to be immunogenic, although there is accumulating evidence that they can also be tolerogenic and induce Ag-specific regulatory T cells (Tregs). However, the mechanism of this Treg induction and the site of Treg action in vivo are yet to be defined. In this study, using the experimental model of interphotoreceptor retinoid-binding protein peptide (1-20)-induced experimental autoimmune uveoretini...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.180.6.3889

Authors


Biester, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Molecular Medicine
Forrester, JV More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
180
Issue:
6
Pages:
3889-3899
Publication date:
2008-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:cb822200-2af8-4359-ae88-1806e10ff114
Source identifiers:
11155
Local pid:
pubs:11155

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP