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Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection.

Abstract:

Understanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their relevance to human disease has been uncertain. In a longitudinal study of malaria sporozoite infection via the natural route, we provide evidence that regulatory T cells have modifying effects on blo...

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Publication status:
Published

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Authors


Walther, M More by this author
Tongren, JE More by this author
Andrews, L More by this author
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Journal:
Immunity
Volume:
23
Issue:
3
Pages:
287-296
Publication date:
2005-09-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:cb80bfcd-e1ac-4464-9275-2265656e41e3
Source identifiers:
33233
Local pid:
pubs:33233

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