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A comparative study of Lapudrine (chlorproguanil) and Maloprim (pyrimethamine and dapsone) as chemoprophylactics against malaria in Gambian children.

Abstract:

A comparison has been made of Lapudrine (chlorproguanil) and Maloprim (pyrimethamine +dapsone) as malaria chemoprophylactics when given every two weeks for 3 years to Gambian children under the age of 5 years. Both drugs produced falls in spleen and malaria parasite rates and an increase in packed cell volume. Maloprim, but not chlorproguanil, significantly reduced the incidence of episodes of fever accompanied by malaria parasitaemia. Children who received Maloprim, but not those who receive...

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Publication status:
Published

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Authors


Greenwood, BM More by this author
Greenwood, AM More by this author
Bradley, AK More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
83
Issue:
2
Pages:
182-188
Publication date:
1989
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:cb7bcd71-fc9f-48b8-9d44-7724efc7ed86
Source identifiers:
102278
Local pid:
pubs:102278

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