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Reactive desorption electrospray ionization linear ion trap mass spectrometry of latest-generation counterfeit antimalarials via noncovalent complex formation.

Abstract:

Desorption electrospray ionization mass spectrometry (DESI MS) is rapidly becoming accepted as a powerful surface characterization tool for a wide variety of samples in the open air. Besides its well-established high-throughput capabilities, a unique feature of DESI is that chemical reactions between the charged spray microdroplets and surface molecules can be exploited to enhance ionization. Here, we present a rapid screening assay for artesunate antimalarials based on reactive DESI. Artesun...

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Publication status:
Published

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Publisher copy:
10.1021/ac062205h

Authors


Nyadong, L More by this author
De Jesus, VR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Fernández, FM More by this author
Journal:
Analytical chemistry
Volume:
79
Issue:
5
Pages:
2150-2157
Publication date:
2007-03-05
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
URN:
uuid:cb6b10b5-afc0-4271-9d39-41ff0b06ea99
Source identifiers:
22087
Local pid:
pubs:22087

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