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SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

Abstract:

The pre-synaptic protein α-synuclein is the main component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Mutations in the α-synuclein gene cause familial forms of Parkinson's disease and dementia with Lewy bodies. We previously described a transgenic mouse line expressing truncated human α-synuclein(1-120) that develops α-synuclein aggregates, striatal dopamine deficiency and reduced locomotion, similar t...

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Publisher copy:
10.1093/brain/awq132

Authors


Journal:
Brain More from this journal
Volume:
133
Issue:
7
Pages:
2032-2044
Publication date:
2010-07-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:243731
UUID:
uuid:cb62ffa0-c8bf-4733-9a5a-13a5ede8b6f9
Local pid:
pubs:243731
Source identifiers:
243731
Deposit date:
2012-12-19

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