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Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

Abstract:

Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities. KO were tested for behavior in approach/avoid conflict tests, responses to repeated forced swim exposure, and locomotor responses under stress and after psychostimulant treatment. The effects of rapid dopamine depletion and treatment with lithium or a GSK-3β ...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2010.08.005

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Journal:
Neurobiology of disease More from this journal
Volume:
40
Issue:
3
Pages:
608-621
Publication date:
2010-12-01
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Language:
English
Keywords:
Pubs id:
pubs:185105
UUID:
uuid:cb61ecd6-01dd-48dd-9e6f-c9cc5bf5e67f
Local pid:
pubs:185105
Source identifiers:
185105
Deposit date:
2012-12-19

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