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DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.

Abstract:

Cdt1 is an essential protein required for licensing of replication origins. Here, we show that in Schizosaccharomyces pombe, Cdt1 is proteolysed in M and G1 phases in response to DNA damage and that this mechanism seems to be conserved from yeast to Metazoa. This degradation does not require Rad3 and Cds1, indicating that it is independent of classic DNA damage and replication checkpoint pathways. Damage-induced degradation of Cdt1 is dependent on Cdt2 and Ddb1, which are components of a Cul4...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7400827

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
EMBO reports
Volume:
7
Issue:
11
Pages:
1134-1139
Publication date:
2006-11-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Source identifiers:
209732
Language:
English
Keywords:
Pubs id:
pubs:209732
UUID:
uuid:cb52085c-e128-4925-a7c7-d416030960f3
Local pid:
pubs:209732
Deposit date:
2013-11-16

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