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Thesis

Linking ageing and arthritis: The role of the longevityrelated SIRT1 molecule in age-related cartilage degeneration and osteoarthritis

Abstract:

Osteoarthritis (OA) is the most common form of arthritis worldwide and is characterised by the progressive degradation of articular cartilage. Ageing is the primary risk factor associated with OA. However, the roles of ageing-related mechanisms in cartilage homeostasis are poorly understood. The class three histone deacetylase, Silent mating type information regulation 2 homolog (SIRT1) has been extensively shown to regulate lifespan in lower organisms and signalling pathways linked to mam...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
More from this funder
Name:
Arthritis Research UK
Grant:
20631
More from this funder
Name:
Arthritis Research UK Centre for Osteoarthritis Pathogenesis
Grant:
20205
More from this funder
Name:
Orthopaedic Research UK
Grant:
509
More from this funder
Name:
Kennedy Trust for Rheumatology Research
Funding agency for:
Sacitharan, P
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:cb519867-d184-44ff-b17f-bee1974f430b
Deposit date:
2017-02-03

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