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Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

Abstract:

Objectives: Although CD8+ T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (PD-1), CD244 and lymphocyte activation gene-3 (LAG-3), which modulate the functional capabilities of CD8+ T cells. Design and methods: Here, we used an array of different human leukocyte antigen (HLA)...

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Publisher:
Lippincott Williams and Wilkins
Journal:
AIDS
Volume:
28
Issue:
14
Pages:
2007-2021
Publication date:
2014-01-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
484282
Language:
English
Keywords:
Pubs id:
pubs:484282
UUID:
uuid:cb458cef-0472-42b5-9a72-ff7c9a0f3809
Local pid:
pubs:484282
Deposit date:
2014-09-18

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