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Journal article

Characterization of in vivo expanded OspA-specific human T-cell clones.

Abstract:

A panel of CD4 T-cell clones was isolated from synovial fluid by single cell flow cytometry from a patient with treatment-resistant Lyme arthritis using a DRB1*0401 major histocompatibility complex (MHC) class II tetramer covalently loaded with outer surface protein A (OspA) peptide164-175, an immunodominant epitope of Borrelia burgdorferi. Sequencing of the T-cell receptors of the OspA reactive clones showed significant skewing of the T-cell receptor repertoire. Of the 101 T-cell clones sequ...

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Publication status:
Published

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Publisher copy:
10.1016/j.clim.2005.02.015

Authors


Ausubel, LJ More by this author
O'Connor, KC More by this author
Baecher-Allen, C More by this author
Trollmo, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
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Journal:
Clinical immunology (Orlando, Fla.)
Volume:
115
Issue:
3
Pages:
313-322
Publication date:
2005-06-05
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
URN:
uuid:cb4204fe-388a-4d45-b900-940f872f306f
Source identifiers:
17256
Local pid:
pubs:17256

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