- Abstract:
-
A panel of CD4 T-cell clones was isolated from synovial fluid by single cell flow cytometry from a patient with treatment-resistant Lyme arthritis using a DRB1*0401 major histocompatibility complex (MHC) class II tetramer covalently loaded with outer surface protein A (OspA) peptide164-175, an immunodominant epitope of Borrelia burgdorferi. Sequencing of the T-cell receptors of the OspA reactive clones showed significant skewing of the T-cell receptor repertoire. Of the 101 T-cell clones sequ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.clim.2005.02.015
-
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- Journal:
- Clinical immunology (Orlando, Fla.)
- Volume:
- 115
- Issue:
- 3
- Pages:
- 313-322
- Publication date:
- 2005-06-05
- DOI:
- EISSN:
-
1521-7035
- ISSN:
-
1521-6616
- URN:
-
uuid:cb4204fe-388a-4d45-b900-940f872f306f
- Source identifiers:
-
17256
- Local pid:
- pubs:17256
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Characterization of in vivo expanded OspA-specific human T-cell clones.
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