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8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1.

Abstract:

Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have established that two closely opposed lesions impair the repair machinery of the cell, but few studies have investigated the processing of tandem lesions. In this study, synthetic double-st...

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Publication status:
Published

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Publisher copy:
10.1667/rr3284

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Radiation research
Volume:
163
Issue:
1
Pages:
79-84
Publication date:
2005-01-01
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
Language:
English
Keywords:
Pubs id:
pubs:130855
UUID:
uuid:cb3fd437-189d-4ce2-be00-c617e2124af9
Local pid:
pubs:130855
Source identifiers:
130855
Deposit date:
2012-12-19

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