- Abstract:
-
The serine and threonine kinase MST1 is the mammalian homolog of Hippo. MST1 is a critical mediator of the migration, adhesion, and survival of T cells; however, these functions of MST1 are independent of signaling by its typical effectors, the kinase LATS and the transcriptional coactivator YAP. The kinase NDR1, a member of the same family of kinases as LATS, functions as a tumor suppressor by preventing T cell lymphomagenesis, which suggests that it may play a role in T cell homeostasis. We...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Publisher copy:
- 10.1126/scisignal.aab2425
-
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- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Signaling Journal website
- Volume:
- 8
- Issue:
- 397
- Pages:
- ra100-ra100
- Publication date:
- 2015-10-06
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1945-0877
- URN:
-
uuid:cb3d0fd2-cac8-4a57-9cf3-46d5d6cf313c
- Source identifiers:
-
580069
- Local pid:
- pubs:580069
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2015
- Notes:
- Copyright 2015 by the American Association for the Advancement of Science; all rights reserved.
Journal article
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
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