Journal article
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
- Abstract:
-
The serine and threonine kinase MST1 is the mammalian homolog of Hippo. MST1 is a critical mediator of the migration, adhesion, and survival of T cells; however, these functions of MST1 are independent of signaling by its typical effectors, the kinase LATS and the transcriptional coactivator YAP. The kinase NDR1, a member of the same family of kinases as LATS, functions as a tumor suppressor by preventing T cell lymphomagenesis, which suggests that it may play a role in T cell homeostasis. We...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Publisher copy:
- 10.1126/scisignal.aab2425
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Swiss National Science Foundation
More from this funder
Funding agency for:
Tang, F
Grant:
SNF 31003A_138287
+ Swiss National Science Foundation
More from this funder
Funding agency for:
Xue, G
Grant:
SNF 31003A_130838
+ Swiss National Science Foundation
More from this funder
Funding agency for:
Schmitz-Rohmer, D
Grant:
SNF 31003A_138287
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Signaling Journal website
- Volume:
- 8
- Issue:
- 397
- Pages:
- ra100-ra100
- Publication date:
- 2015-10-06
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1945-0877
- Source identifiers:
-
580069
Item Description
- Pubs id:
-
pubs:580069
- UUID:
-
uuid:cb3d0fd2-cac8-4a57-9cf3-46d5d6cf313c
- Local pid:
- pubs:580069
- Deposit date:
- 2015-12-15
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2015
- Notes:
- Copyright 2015 by the American Association for the Advancement of Science; all rights reserved.
If you are the owner of this record, you can report an update to it here: Report update to this record