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The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

Abstract:

The serine and threonine kinase MST1 is the mammalian homolog of Hippo. MST1 is a critical mediator of the migration, adhesion, and survival of T cells; however, these functions of MST1 are independent of signaling by its typical effectors, the kinase LATS and the transcriptional coactivator YAP. The kinase NDR1, a member of the same family of kinases as LATS, functions as a tumor suppressor by preventing T cell lymphomagenesis, which suggests that it may play a role in T cell homeostasis. We...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scisignal.aab2425

Authors


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Funding agency for:
Tang, F
Grant:
SNF 31003A_138287
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Funding agency for:
Xue, G
Grant:
SNF 31003A_130838
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Funding agency for:
Hergovich, A
Grant:
090090/Z/09/Z
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Funding agency for:
Gill, J
Grant:
KFS 02743-02-2011
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Funding agency for:
Schmitz-Rohmer, D
Grant:
SNF 31003A_138287
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Signaling Journal website
Volume:
8
Issue:
397
Pages:
ra100-ra100
Publication date:
2015-10-06
DOI:
EISSN:
1937-9145
ISSN:
1945-0877
Source identifiers:
580069
Pubs id:
pubs:580069
UUID:
uuid:cb3d0fd2-cac8-4a57-9cf3-46d5d6cf313c
Local pid:
pubs:580069
Deposit date:
2015-12-15

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