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Journal article

Gene-environment interaction in a conditional NMDAR-knockout model of schizophrenia

Abstract:

Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive symptom domains of schizophrenia in a mouse line modeling NMDA-receptor (NMDAR) hypofunction in forebrain inhibitory interneurons (Grin1 ΔPpp1r2 ). We find that Grin1 ΔPpp1r2 mice, when group-housed in highly enriched cages, appear largely no...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fnbeh.2018.00332

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-3024-7595
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Name:
Medical Research Council
Grant:
MR/L01095X/1
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Name:
Wellcome Trust
Grant:
098896
Publisher:
Frontiers Media
Journal:
Frontiers in Behavioral Neuroscience More from this journal
Volume:
12
Article number:
332
Publication date:
2019-01-10
Acceptance date:
2018-12-17
DOI:
EISSN:
1662-5153
Pmid:
30687034
Language:
English
Keywords:
Pubs id:
pubs:967005
UUID:
uuid:cb3a3421-65f9-4405-b027-4ab9d3fcf352
Local pid:
pubs:967005
Source identifiers:
967005
Deposit date:
2019-04-29

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