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Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis

Abstract:

Objective: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). Subjects and methods: Samples from 3582 individuals from the Rotterdam Study, the Genetics osteoArthritis and Progression (GARP), the Chingford Study and the TwinsUK cohort were assayed using enzyme-linked immune sorbent assays. Log of concentration levels were correla...

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Publisher copy:
10.1016/j.joca.2014.02.007

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Journal:
Osteoarthritis and Cartilage
Volume:
22
Issue:
5
Pages:
683-689
Publication date:
2014-05-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:cb388965-201b-4525-85bb-1c5d7458e0a3
Source identifiers:
466949
Local pid:
pubs:466949

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