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Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2).

Abstract:

We examined the effects of insulin-like growth factors (IGFs) and insulin on erythropoietin (EPO) production by human hepatoma cells (Hep G2). Compared with normoxia (20% O2), EPO production by Hep G2 cells during a 72-h incubation was stimulated fivefold by exposure to low oxygen tension (1% O2) and nearly threefold by exposure to cobalt chloride (100 microM). IGF-I caused a concentration-dependent attenuation of EPO formation under normoxic conditions and inhibited (maximally 50%) EPO produ...

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Publication status:
Published

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Journal:
American journal of physiology
Volume:
263
Issue:
2 Pt 1
Pages:
C474-C479
Publication date:
1992-08-01
ISSN:
0002-9513
Source identifiers:
74058

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