- Abstract:
-
Beat-to-beat variability in repolarization (BVR) has been proposed as an arrhythmic risk marker for disease and pharmacological action. The mechanisms are unclear but BVR is thought to be a cell level manifestation of ion channel stochasticity, modulated by cell-to-cell differences in ionic conductances. In this study, we describe the construction of an experimentally-calibrated set of stochastic cardiac cell models that captures both BVR and cell-to-cell differences in BVR displayed in isola...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.4mb)
-
- Publisher copy:
- 10.1371/journal.pone.0151461
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS ONE Journal website
- Volume:
- 11
- Issue:
- 3
- Pages:
- e0151461
- Publication date:
- 2016
- DOI:
- EISSN:
-
1932-6203
- URN:
-
uuid:cb35865e-ea4a-438c-95db-3a89932efa21
- Source identifiers:
-
614129
- Local pid:
- pubs:614129
- Paper number:
- 3
- Language:
- English
- Copyright holder:
- Pueyo et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Pueyo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition
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