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Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition

Abstract:

Beat-to-beat variability in repolarization (BVR) has been proposed as an arrhythmic risk marker for disease and pharmacological action. The mechanisms are unclear but BVR is thought to be a cell level manifestation of ion channel stochasticity, modulated by cell-to-cell differences in ionic conductances. In this study, we describe the construction of an experimentally-calibrated set of stochastic cardiac cell models that captures both BVR and cell-to-cell differences in BVR displayed in isola...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0151461

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Publisher:
Public Library of Science Publisher's website
Journal:
PloS ONE Journal website
Volume:
11
Issue:
3
Pages:
e0151461
Publication date:
2016-01-01
Acceptance date:
2016-02-29
DOI:
EISSN:
1932-6203
Source identifiers:
614129
Language:
English
Pubs id:
pubs:614129
UUID:
uuid:cb35865e-ea4a-438c-95db-3a89932efa21
Local pid:
pubs:614129
Deposit date:
2016-04-13

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