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Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli

Abstract:

Cholinergic interneurons are key components of striatal microcircuits. In primates, tonically active neurons (putative cholinergic interneurons) exhibit multiphasic responses to motivationally salient stimuli that mirror those of midbrain dopamine neurons and together these two systems mediate reward-related learning in basal ganglia circuits. Here, we addressed the potential contribution of cortical and thalamic excitatory inputs to the characteristic multiphasic responses of cholinergic int...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/JNEUROSCI.4627-13.2014

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
ORCID:
0000-0001-6821-0264
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Sub department:
BNDU
Role:
Author
ORCID:
0000-0001-7141-7071
More by this author
Role:
Author
ORCID:
0000-0002-5008-8405
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1594-3349
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Name:
Medical Research Council
Grant:
MC_UU_12020/1
More from this funder
Name:
Parkinson's UK
Grant:
G-0806
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
34
Issue:
8
Pages:
3101-3117
Publication date:
2014-02-19
Acceptance date:
2014-01-23
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
24553950

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