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HIV-1 DNA predicts disease progression and post-treatment virological control.

Abstract:

In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.03821

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Williams, J
Grant:
NDM Studentship
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Funding agency for:
Phillips, R
Grant:
SPARTAC Trial Grant: (069598/Z/02/Z
More from this funder
Funding agency for:
Phillips, R
Grant:
SPARTAC Trial Grant: (069598/Z/02/Z
More from this funder
Funding agency for:
Frater, A
Publisher:
eLife Sciences Publications, Ltd Publisher's website
Journal:
eLife Journal website
Volume:
2014;3:e03821
Pages:
e03821
Publication date:
2014-01-01
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Source identifiers:
484140

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