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The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.

Abstract:

Resistance to O(6-)alkylating agents can be overcome by depletion of the DNA repair protein, O(6)-alkylguanine DNA alkyltransferase. Inhibitors of this protein act as pseudosubstrates and, so far, O(6)-benzylguanine and lomeguatrib have been tested in clinical trials. Inherently non-toxic, optimum doses for protein depletion have been established for both agents. Myelosuppression of alkylating agents is significantly enhanced when used in combination with these agents, necessitating significa...

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Publication status:
Published

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Publisher copy:
10.1517/13543784.16.10.1573
Journal:
Expert opinion on investigational drugs More from this journal
Volume:
16
Issue:
10
Pages:
1573-1584
Publication date:
2007-10-01
DOI:
EISSN:
1744-7658
ISSN:
1354-3784
Language:
English
Keywords:
Pubs id:
pubs:315748
UUID:
uuid:cb25f9b1-5131-4fa4-984b-9fe491c55bb0
Local pid:
pubs:315748
Source identifiers:
315748
Deposit date:
2013-11-16

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