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Journal article

Centrioles, centrosomes, and cilia in health and disease.

Abstract:

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes, cilia, and flagella. Here we review recent advances in our understanding of the function and biogenesis of these organelles, and we emphasize their connection to human disease. Deregulation of centrosome numbers has long been proposed to contribute to genome instability and tumor formation, whereas mutations in centrosomal proteins have recently been genetically linked to microcephaly and dwarfism. Fi...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2009.10.036

Authors


Journal:
Cell
Volume:
139
Issue:
4
Pages:
663-678
Publication date:
2009-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:cb1ce605-ca5e-450a-953d-87e398e5750d
Source identifiers:
223417
Local pid:
pubs:223417

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