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The origins and end-organ consequence of pre-eclampsia

Abstract:

Pre-eclampsia is a multisystem disorder with profound implications for both mother and fetus. Its origins lie in the earliest stages of pregnancy. Abnormal interactions between fetal trophoblast and maternal decidua, including the cells of the maternal immune system, lead to inadequate placental invasion and maternal vascular remodelling. However, abnormal placentation is only one steop in the cascade of events that ultimately result in maternal organ dysfunction. Pre-existing maternal condit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of British Columbia, Vancouver, BC, Canada
Department:
Department of Obstetrics and Gynaecology
Role:
Author
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Institution:
"St George Hospital", "University of New South Wales, Sydney, NSW, Australia"
Department:
Department of Renal Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Publisher:
Elsevier
Journal:
Best Practice & Research Clinical Obstetrics and Gynaecology More from this journal
Volume:
25
Issue:
4
Pages:
435-447
Publication date:
2011-08-01
DOI:
ISSN:
1521-6934
Language:
English
Keywords:
Subjects:
UUID:
uuid:cb1c576b-1085-4fac-8b31-3bc24af6b3de
Local pid:
ora:5821
Deposit date:
2011-10-26

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