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Hepatitis B virus (HBV) adaptation to the CD8+ T cell response: consequences for host and pathogen

Abstract:

Chronic viral hepatitis infections are a major public health concern, with an estimated 290 million individuals infected with hepatitis B virus (HBV) globally. This virus has been a passenger in human populations for >30,000 years, and remains highly prevalent in some settings. In order for this endemic pathogen to persist, viral adaptation to host immune responses is pre-requisite. Here we focus on the interplay between HBV infection and the CD8+ T cell response. We present the evidence t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.01561

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; BDI-NDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Oxford college:
Harris Manchester College
ORCID:
0000-0002-4036-4269
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
1561
Publication date:
2018-07-16
Acceptance date:
2018-06-25
DOI:
EISSN:
1664-3224
Pubs id:
pubs:859542
URN:
uri:cb1b788b-d01b-48ea-ac7d-67b67c95e78a
UUID:
uuid:cb1b788b-d01b-48ea-ac7d-67b67c95e78a
Local pid:
pubs:859542

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