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5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies.

Abstract:

BACKGROUND AND OBJECTIVES: Mesenchymal stem/progenitor cells (MSCs) are multipotent progenitors that differentiate into such lineages as bone, fat, cartilage and stromal cells that support haemopoiesis. Bone marrow MSCs can also contribute to cardiac repair, although the mechanism for this is unclear. Here, we examine the potential of MSCs from different sources to generate cardiomyocytes in vitro, as a means for predicting their therapeutic potential after myocardial infarction. MATERIALS A...

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Publication status:
Published

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Journal:
Vox sanguinis
Volume:
95
Issue:
2
Pages:
137-148
Publication date:
2008-08-01
DOI:
EISSN:
1423-0410
ISSN:
0042-9007
Source identifiers:
324167

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